Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel regulation of PLCζ activity via its XY-linker

19 Jul 2011

Abstract excerpt

The XY-linker region of somatic cell PLC (phospholipase)-β, -γ, -δ and -ε isoforms confers potent catalytic inhibition, suggesting a common auto-regulatory role. Surprisingly, the sperm PLCζ XY-linker does not mediate auto-inhibition. Unlike for somatic PLCs, the absence of the PLCζ XY-linker significantly diminishes both in vitro PIP2 (phosphatidylinositol 4,5-bisphosphate) hydrolysis and in vivo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Microtubule and mitosis dynamics
Share to Reproductive Biology and Fertility
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21767260
DOI: 10.1042/bj20110953

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel regulation of PLCζ activity via its XY-linkerPMID 21767260Read ↗

Novel signalling mechanism and clinical applications of sperm-specific PLCζSemantic proximity Read ↗

Chimeras of sperm PLC reveal disparate protein domain functions in the generation of intracellular Ca2+ oscillations in mammalian eggs at fertilizationSemantic proximity Read ↗

Sperm PLCζ: From structure to Ca<sup>2+</sup> oscillations, egg activation and therapeutic potentialSemantic proximity Read ↗

SPERM FACTORS AND EGG ACTIVATION: The structure and function relationship of sperm PLCZ1Semantic proximity Read ↗

Essential Role of Sperm-Specific PLC-Zeta in Egg Activation and Male Factor Infertility: An UpdateSemantic proximity Read ↗

The role and mechanism of action of sperm PLC-zeta in mammalian fertilisationSemantic proximity Read ↗

PLCζ, a sperm-specific PLC and its potential role in fertilizationSemantic proximity Read ↗

PLCζ and its role as a trigger of development in vertebratesSemantic proximity Read ↗

PLCζ(zeta): A sperm protein that triggers Ca2+ oscillations and egg activation in mammalsSemantic proximity Read ↗

Essential Role of the EF-hand Domain in Targeting Sperm Phospholipase Cζ to Membrane Phosphatidylinositol 4,5-Bisphosphate (PIP2).Semantic proximity Read ↗

Phospholipase C zeta (PLCζ) and male infertility: Clinical update and topical developments.Semantic proximity Read ↗

The sperm phospholipase C-ζ and Ca2+ signalling at fertilization in mammalsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.