Genetic predictors of taxane-induced neurotoxicity in a SWOG phase III intergroup adjuvant breast cancer treatment trial (S0221).

doi:10.1007/s10549-011-1671-3

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Article

Genetic predictors of taxane-induced neurotoxicity in a SWOG phase III intergroup adjuvant breast cancer treatment trial (S0221).

Breast cancer research and treatment - 1 Dec 2011

Sucheston Lara E, Zhao Hua, Yao Song, Zirpoli Gary, Liu Song, Barlow William E, Moore Halle C F, Thomas Budd G, Hershman Dawn L, Davis Warren, Ciupak Gregory L, Stewart James A, Isaacs Claudine, Hobday Timothy J, Salim Muhammad, Hortobagyi Gabriel N, Gralow Julie R, Livingston Robert B, Albain Kathy S, Hayes Daniel F, Ambrosone Christine B

Abstract excerpt

Taxanes have resulted in improved survival for breast cancer patients, but often cause neurological toxicities. Identification of biomarkers related to toxicities could be important for dictating treatment regimen. We evaluated single nucleotide polymorphisms (SNPs) in the Fanconi Anemia (FA)/BRCA pathway in relation to grade 3/4 neurotoxicities in patients (n = 888) from SWOG0221, a phase III adjuvant trial for...

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Identifiers

PMID: 21766209
DOI: 10.1007/s10549-011-1671-3
PMCID: PMC3532924

Genes

FANCD2
BRCA1

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