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Article

Regulation of Ikaros function by casein kinase 2 and protein phosphatase 1

1 Jan 2011

Abstract excerpt

The Ikaros gene encodes a zinc finger, DNA-binding protein that regulates gene transcription and chromatin remodeling. Ikaros is a master regulator of hematopoiesis and an established tumor suppressor. Moderate alteration of Ikaros activity (e.g. haploinsufficiency) appears to be sufficient to promote malignant transformation in human hematopoietic cells. This raises questions about the mechanisms that normally...

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PMID: 21765978
DOI: 10.4331/wjbc.v2.i6.126

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