Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia

29 Jul 2015

Abstract excerpt

Ikaros (IKZF1) is a tumor suppressor that binds DNA and regulates expression of its target genes. The mechanism of Ikaros activity as a tumor suppressor and the regulation of Ikaros function in leukemia are unknown. Here, we demonstrate that Ikaros controls cellular proliferation by repressing expression of genes that promote cell cycle progression and the phosphatidylinositol-3 kinase (PI3K) pathway. We show...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Acute Myeloid Leukemia Research
Share to Childhood Cancer Survivors' Quality of Life

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26219304
DOI: 10.1182/blood-2015-06-651505

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemiaPMID 26219304Read ↗

IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Cellular signaling and epigenetic regulation of gene expression in leukemiaSemantic proximity Read ↗

Regulation of Ikaros function by casein kinase 2 and protein phosphatase 1Semantic proximity Read ↗

Mechanistic Basis for In Vivo Therapeutic Efficacy of CK2 Inhibitor CX-4945 in Acute Myeloid LeukemiaSemantic proximity Read ↗

Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre–B ALLSemantic proximity Read ↗

Ikaros and Tumor Suppression in Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Therapeutic targeting of CK2 in acute and chronic leukemiasSemantic proximity Read ↗

Ikaros Regulates microRNA Networks in Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Ikaros: Exploiting and targeting the hematopoietic stem cell niche in B-progenitor acute lymphoblastic leukemia.Semantic proximity Read ↗

Ikaros Regulates microRNA Networks in Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Understanding the biology of CRLF2-overexpressing acute lymphoblastic leukemia.Semantic proximity Read ↗

Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: implications for a new mechanism of resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.