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Article

Genetic inactivation of Ikaros is a rare event in human T-ALL.

Leukemia research - 1 Apr 2010

Marçais Ambroise, Jeannet Robin, Hernandez Lucie, Soulier Jean, Sigaux François, Chan Susan, Kastner Philippe

Abstract excerpt

The Ikaros (Ikzf1) gene, encoding a transcription regulator, is a major tumor suppressor in B-cell acute lymphoblastic leukemia (B-ALL). In the mouse, however, loss of Ikaros is primarily associated with T-ALL development. Whether Ikaros is also implicated in human T-ALL remains unclear. We studied Ikaros in 25 human T-ALL samples from diverse molecular subtypes at the mRNA, protein, sequence and genomic copy...

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Source

Identifiers

PMID: 19796813
DOI: 10.1016/j.leukres.2009.09.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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