Article
DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase.
Cell cycle (Georgetown, Tex.) - 1 Jan 2015
Brazina Jan, Svadlenka Jan, Macurek Libor, Andera Ladislav, Hodny Zdenek, Bartek Jiri, Hanzlikova Hana
Abstract excerpt
Death domain-associated protein 6 (DAXX) is a histone chaperone, putative regulator of apoptosis and transcription, and candidate modulator of p53-mediated gene expression following DNA damage. DAXX becomes phosphorylated upon DNA damage, however regulation of this modification, and its relationship to p53 remain unclear. Here we show that in human cells exposed to ionizing radiation or genotoxic drugs etoposide...
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