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Article

Targeted Deletion of Neuropeptide Y (NPY) Modulates Experimental Colitis

30 Sept 2008

Abstract excerpt

BACKGROUND: Neurogenic inflammation plays a major role in the pathogenesis of inflammatory bowel disease (IBD). We examined the role of neuropeptide Y (NPY) and neuronal nitric oxide synthase (nNOS) in modulating colitis. METHODS: Colitis was induced by administration of dextran sodium sulphate (3% DSS) or streptomycin pre-treated Salmonella typhimurium (S.T.) in wild type (WT) and NPY (NPY(-/-)) knockout mice....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18836554
DOI: 10.1371/journal.pone.0003304

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