Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vanilloid receptor (TRPV1)-deficient mice show increased susceptibility to dinitrobenzene sulfonic acid induced colitis.

Journal of molecular medicine (Berlin, Germany) - 1 Feb 2006

Massa F, Sibaev A, Marsicano G, Blaudzun H, Storr M, Lutz B

Abstract excerpt

In the human colon, vanilloid receptor TRPV1 is overexpressed both in afferent nerve terminals and in epithelial cells during inflammation. In the past years, pharmacological experiments using TRPV1 agonists and antagonists revealed that TRPV1 receptors may play proinflammatory and protective roles in the gastrointestinal tract. Here, we applied a genetic approach to define the role of TRPV1 and analyzed the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzenesulfonates
Share to Colitis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to TRPV1 gene

Share to Genetic Predisposition to Disease

Share to Mice, Knockout

Share to Severity of Illness Index

Share to TRPV Cation Channels

Source

Identifiers

PMID: 16389550
DOI: 10.1007/s00109-005-0016-2

Genes

TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vanilloid receptor (TRPV1)-deficient mice show increased susceptibility to dinitrobenzene sulfonic acid induced colitis.PMID 16389550Read ↗

Vanilloid receptor-1 regulates neurogenic inflammation in colon and protects mice from colon cancer.Semantic proximity Read ↗

TRPA1 and substance P mediate colitis in mice.Semantic proximity Read ↗

Mice lacking cannabinoid CB1-, CB2-receptors or both receptors show increased susceptibility to trinitrobenzene sulfonic acid (TNBS)-induced colitis.Semantic proximity Read ↗

Colon-to-hind paw cross-organ sensitization is partially mediated by TrkB.T1-facilitated spinal neuroinflammation to activate lumbar DRG neuronsSemantic proximity Read ↗

Colon Innervating TRPA1 Positive Nociceptors Influence Mucosal Health In MiceSemantic proximity Read ↗

Montelukast suppresses the development of irritable bowel syndrome phenotype possibly through modulating NF-κB signaling in an experimental model.Semantic proximity Read ↗

Piezo1-specific Deletion in Macrophage Protects the Progression of Chronic Inflammatory Bowel Disease in MiceSemantic proximity Read ↗

Altered Prostasin (CAP1/Prss8) Expression Favors Inflammation and Tissue Remodeling in DSS-induced Colitis.Semantic proximity Read ↗

Differences in spinal distribution and neurochemical phenotype of colonic afferents in mouse and rat.Semantic proximity Read ↗

Identification of Arginine-Vasopressin Receptor 1a (Avpr1a/Avpr1a) as a Novel Candidate Gene for Chronic Visceral Pain Sheds Light on the Potential Role of Enteric Neurons in the Development of Visceral Hypersensitivity.Semantic proximity Read ↗

Investigation of TRPV1 loss-of-function phenotypes in TRPV1 Leu206Stop mice generated by N-ethyl-N-nitrosourea mutagenesis.Semantic proximity Read ↗

DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colonSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.