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Article

Interactions between environmental factors and polymorphisms in angiogenesis pathway genes in esophageal adenocarcinoma risk: a case-only study.

Cancer - 1 Feb 2012

Zhai Rihong, Zhao Yang, Liu Geoffrey, Ter-Minassian Monica, Wu I-Chen, Wang Zhaoxi, Su Li, Asomaning Kofi, Chen Feng, Kulke Matthew H, Lin Xihong, Heist Rebecca S, Wain John C, Christiani David C

Abstract excerpt

BACKGROUND: Gastroesophageal reflux disease (GERD), higher body mass index (BMI), smoking, and genetic variants in angiogenic pathway genes have been individually associated with increased risk of esophageal adenocarcinoma. However, how angiogenic gene polymorphisms and environmental factors jointly affect esophageal adenocarcinoma development remains unclear. METHODS: By using a case-only design (n = 335), the...

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Identifiers

PMID: 21751195
DOI: 10.1002/cncr.26325
PMCID: PMC3193872

Genes

PDGFRB
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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