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Article

Interactions between genetic polymorphisms in the apoptotic pathway and environmental factors on esophageal adenocarcinoma risk.

Carcinogenesis - 1 Apr 2011

Wu I-Chen, Zhao Yang, Zhai Rihong, Liu Chen-yu, Chen Feng, Ter-Minassian Monica, Asomaning Kofi, Su Li, Heist Rebecca S, Kulke Matthew H, Liu Geoffrey, Christiani David C

Abstract excerpt

How genetic variations in apoptosis pathway interact with environmental factors to contribute to esophageal adenocarcinoma (EA) risk has not been comprehensively investigated. We conducted a case-only analysis in 335 Caucasian EA patients that were genotyped for 242 single nucleotide polymorphisms (SNPs) in 43 apoptotic genes. Gene-environment interactions were assessed using a two-step approach. First, random...

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Identifiers

PMID: 21212151
DOI: 10.1093/carcin/bgq287
PMCID: PMC3066416

Genes

BCL2
CASP7
PERP

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