Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Candidate-Pathway Approach to Identify Gene-Environment Interactions: Analyses of Colon Cancer Risk and Survival.

Journal of the National Cancer Institute - 1 Sept 2015

Sharafeldin Noha, Slattery Martha L, Liu Qi, Franco-Villalobos Conrado, Caan Bette J, Potter John D, Yasui Yutaka

Abstract excerpt

BACKGROUND: Genetic association studies have traditionally focused on associations between individual single nucleotide polymorphisms (SNPs) and disease. Standard analysis ignores interactions between multiple SNPs and environmental exposures explaining a small portion of disease heritability: the often-cited issue of "missing heritability." METHODS: We present a novel three-step analytic framework for modeling...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Drinking
Share to Bone Morphogenetic Protein Receptors, Type II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colonic Neoplasms

Share to Dietary Proteins

Share to Gene-Environment Interaction

Share to Neovascularization, Pathologic

Share to Proportional Hazards Models

Share to Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 26072521
DOI: 10.1093/jnci/djv160
PMCID: PMC4651103

Genes

FLT1
BMP1
BMP4
BMPR2
KDR
TLR2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Candidate-Pathway Approach to Identify Gene-Environment Interactions: Analyses of Colon Cancer Risk and Survival.PMID 26072521Read ↗

Multiple Gene-Environment Interactions on the Angiogenesis Gene-Pathway Impact Rectal Cancer Risk and Survival.Semantic proximity Read ↗

Using gene-environment interactions to explore pathways for colorectal cancer risk.Semantic proximity Read ↗

Integrative network modeling of colorectal cancer reveals diagnostic signatures and therapeutic targetsSemantic proximity Read ↗

VEGFA, FLT1, KDR and colorectal cancer: assessment of disease risk, tumor molecular phenotype, and survival.Semantic proximity Read ↗

Causal relationships of inflammatory cytokines and serum metabolites with colorectal carcinoma: A Mendelian randomization study.Semantic proximity Read ↗

Modifiable pathways for colorectal cancer: a mendelian randomisation analysis.Semantic proximity Read ↗

Causal roles and clinical utility of cardiovascular proteins in colorectal cancer risk: a multi-modal study integrating mendelian randomization, expression profiling, and survival analysis.Semantic proximity Read ↗

Interactions between environmental factors and polymorphisms in angiogenesis pathway genes in esophageal adenocarcinoma risk: a case-only study.Semantic proximity Read ↗

Novel insights into the molecular mechanisms underlying risk of colorectal cancer from smoking and red/processed meat carcinogens by modeling exposure in normal colon organoidsSemantic proximity Read ↗

Characterization of Additive Gene-environment Interactions For Colorectal Cancer Risk.Semantic proximity Read ↗

Genome-wide diet-gene interaction analyses for risk of colorectal cancer.Semantic proximity Read ↗

TGF-β-pathway-based polygenic risk score modifies the association between red meat intake and colorectal cancer risk: Application of a novel pathway-based PRS methodSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.