Article
Genetic polymorphisms of VEGF, interactions with cigarette smoking exposure and esophageal adenocarcinoma risk.
Carcinogenesis - 1 Dec 2008
Zhai Rihong, Liu Geoffrey, Asomaning Kofi, Su Li, Kulke Matthew H, Heist Rebecca S, Nishioka Norman S, Lynch Thomas J, Wain John C, Lin Xihong, Christiani David C
Abstract excerpt
Vascular endothelial growth factor (VEGF) is a major regulator of angiogenesis in the process of tumor growth and metastasis in esophageal adenocarcinoma (EA). Polymorphisms in the VEGF gene have been associated with altered VEGF expression and plasma VEGF levels. We hypothesized that polymorphisms of VEGF may contribute to EA risk. Functional polymorphisms in the VEGF gene (-460C/T, +405C/G and +936C/T) were...
Topics
- Adenocarcinoma
- Aged
- Esophageal Neoplasms
- Female
- Genetic Predisposition to Disease
- Genotype
- Haplotypes
- Humans
- Male
- Middle Aged
- Polymorphism, Single Nucleotide