Article
Wld(S) reduces paraquat-induced cytotoxicity via SIRT1 in non-neuronal cells by attenuating the depletion of NAD.
PloS one - 1 Jan 2011
Yu Qiujing, Wang Ting, Zhou Xuexia, Wu Jingxia, Chen Xingmiao, Liu Yang, Wu Dongmei, Zhai Qiwei
Abstract excerpt
Wld(S) is a fusion protein with NAD synthesis activity, and has been reported to protect axonal and synaptic compartments of neurons from various mechanical, genetic and chemical insults. However, whether Wld(S) can protect non-neuronal cells against toxic chemicals is largely unknown. Here we found that Wld(S) significantly reduced the cytotoxicity of bipyridylium herbicides paraquat and diquat in mouse...
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