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CHD7 promotes glioblastoma cell motility and invasiveness through transcriptional modulation of an invasion signature

8 Mar 2019

Abstract excerpt

Chromatin remodeler proteins exert an important function in promoting dynamic modifications in the chromatin architecture, performing a central role in regulating gene transcription. Deregulation of these molecular machines may lead to striking perturbations in normal cell function. The CHD7 gene is a member of the chromodomain helicase DNA-binding family and, when mutated, has been shown to be the cause of the...

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PMID: 30850678
DOI: 10.1038/s41598-019-39564-w

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