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Essential role of the Hedgehog signaling pathway in human glioma‐initiating cells

31 Mar 2011

Abstract excerpt

Recent findings have demonstrated that malignant tumors, including glioblastoma multiforme, contain cancer-initiating cells (also known as cancer stem cells), which self-renew and are malignant, with features of tissue-specific stem cells. As these cells are resistant to irradiation and anti-cancer drugs, it is important to characterize them and find targeting therapies. In this study, we established two primary...

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PMID: 21453386
DOI: 10.1111/j.1349-7006.2011.01943.x

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