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Article

Modulation of histamine H(2) receptor signalling by G-protein-coupled receptor kinase 2 and 3.

British journal of pharmacology - 1 Dec 2000

Rodriguez-Pena M S, Timmerman H, Leurs R

Abstract excerpt

To evaluate the role of G-protein-coupled receptor kinases (GRK) in the desensitization of the histamine H(2) receptor, the H(2) receptor was transiently cotransfected with GRK2, 3, 5 or 6 in COS-7 cells and the cyclic AMP levels in response to histamine were studied. Coexpression of the H(2) receptor with GRK2 and 3 significantly decreased both the basal cyclic AMP levels and the cyclic AMP response to 100...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Dose-Response Relationship, Drug

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Source

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Identifiers

PMID: 11139450
DOI: 10.1038/sj.bjp.0703676
PMCID: PMC1572484

Genes

GRK2
GRK5
GRK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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