Article
Controlled and cardiac-restricted overexpression of the arginine vasopressin V1A receptor causes reversible left ventricular dysfunction through Gαq-mediated cell signaling.
Circulation - 2 Aug 2011
Li Xue, Chan Tung O, Myers Valerie, Chowdhury Ibrul, Zhang Xue-Qian, Song Jianliang, Zhang Jin, Andrel Jocelyn, Funakoshi Hajime, Robbins Jeffrey, Koch Walter J, Hyslop Terry, Cheung Joseph Y, Feldman Arthur M
Abstract excerpt
BACKGROUND: [Arg8]-vasopressin (AVP) activates 3 G-protein-coupled receptors: V1A, V2, and V1B. The AVP-V1A receptor is the primary AVP receptor in the heart; however, its role in cardiac homeostasis is controversial. To better understand AVP-mediated signaling in the heart, we created a transgenic mouse with controlled overexpression of the V1A receptor. METHODS AND RESULTS: The V1A receptor transgene was placed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.