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Mutation of RNA polymerase beta subunit (rpoB) promotes hVISA-to-VISA phenotypic conversion of strain Mu3.

Antimicrobial agents and chemotherapy - 1 Sept 2011

Matsuo Miki, Hishinuma Tomomi, Katayama Yuki, Cui Longzhu, Kapi Maria, Hiramatsu Keiichi

Abstract excerpt

The clinical vancomycin-intermediate Staphylococcus aureus (VISA) strain Mu50 carries two mutations in the vraSR and graRS two-component regulatory systems (TCRSs), namely, vraS(I5N) and graR(N197S) (hereinafter designated graR). The clinical heterogeneously vancomycin-intermediate S. aureus (hVISA) strain Mu3 shares with Mu50 the mutation in vraS that encodes the VraS two-component histidine kinase. Previously,...

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Identifiers

PMID: 21746940
DOI: 10.1128/AAC.00398-11
PMCID: PMC3165293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Mutation of RNA polymerase beta subunit (rpoB) promotes hVISA-to-VISA phenotypic conversion of strain Mu3.PMID 21746940Read ↗

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