Article
Genetic pathway in acquisition and loss of vancomycin resistance in a methicillin resistant Staphylococcus aureus (MRSA) strain of clonal type USA300.
PLoS pathogens - 1 Feb 2012
Gardete Susana, Kim Choonkeun, Hartmann Boris M, Mwangi Michael, Roux Christelle M, Dunman Paul M, Chambers Henry F, Tomasz Alexander
Abstract excerpt
An isolate of the methicillin-resistant Staphylococcus aureus (MRSA) clone USA300 with reduced susceptibility to vancomycin (SG-R) (i.e, vancomycin-intermediate S. aureus, VISA) and its susceptible "parental" strain (SG-S) were recovered from a patient at the end and at the beginning of an unsuccessful vancomycin therapy. The VISA phenotype was unstable in vitro generating a susceptible revertant strain (SG-rev)....
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