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Article

Mutation of RNA polymerase β-subunit gene promotes heterogeneous-to-homogeneous conversion of β-lactam resistance in methicillin-resistant Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 Oct 2013

Aiba Yoshifumi, Katayama Yuki, Hishinuma Tomomi, Murakami-Kuroda Hiroko, Cui Longzhu, Hiramatsu Keiichi

Abstract excerpt

Three types of phenotypic expression of β-lactam resistance have been reported in methicillin-resistant Staphylococcus aureus (MRSA): heterogeneous, homogeneous, and Eagle-type resistance. Heterogeneous-to-homogeneous conversion of β-lactam resistance is postulated to be caused by a chromosomal mutation (chr*) in addition to the expression of the mecA gene. Eagle-type resistance is a unique phenotype of chr*...

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Identifiers

PMID: 23877693
DOI: 10.1128/AAC.00720-13
PMCID: PMC3811421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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