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Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin

1 Jan 1990

Abstract excerpt

Doxorubicin, a DNA-intercalator, is one of several anti-cancer drugs that have been found to stabilizes topoisomerase II cleavage complexes at drug-specific DNA sites. The distribution and DNA sequence environments of doxorubicin-stabilized sites were determined in the SV40 genome. The sites were found to be most concentrated in the major nuclear matrix-associated region and nearly absent in the vicinity of the...

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PMID: 2174543
DOI: 10.1093/nar/18.22.6611

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Source receipt: pubmed, retrieved 7 Sept 2026.

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