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Article

Base mutation analysis of topoisomerase II-idarubicin-DNA ternary complex formation. Evidence for enzyme subunit cooperativity in DNA cleavage.

Nucleic acids research - 25 Jun 1994

Bigioni M, Zunino F, Capranico G

Abstract excerpt

Antitumor drugs, such as anthracyclines, interfere with mammalian DNA topoisomerase II by forming a ternary complex, DNA-drug-enzyme, in which DNA strands are cleaved and covalently linked to the enzyme. In this work, a synthetic 36-bp DNA oligomer derived from SV40 and mutated variants were used to determine the effects of base mutations on DNA cleavage levels produced by murine topoisomerase II with and without...

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Identifiers

PMID: 8036155
DOI: 10.1093/nar/22.12.2274
PMCID: PMC523684

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