Article
DNA sequence specificity of doxorubicin-induced mutational damage in uvrB- Escherichia coli.
Cancer research - 1 Aug 1991
Anderson R D, Veigl M L, Baxter J, Sedwick W D
Abstract excerpt
In the absence of excision repair, doxorubicin caused a striking (41-fold) increase in the frequency of large deletion mutations extending from the lac operator (lacO) into the lac repressor gene (lacI) of Escherichia coli. In contrast, there was only a 2-fold increase in the frequency of small deletions despite a 3-fold increase in overall mutation frequency. The 5'-endpoints of doxorubicin-induced lacO and...
Topics
- Base Sequence
- DNA Damage
- DNA Repair
- DNA, Bacterial
- Doxorubicin
- Escherichia coli
- Lac Operon
- Molecular Sequence Data
- Mutation