Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variants in the ATM-BRCA2-CHEK2 axis predispose to chronic lymphocytic leukemia.

Blood - 15 Jul 2006

Rudd Matthew F, Sellick Gabrielle S, Webb Emily L, Catovsky Daniel, Houlston Richard S

Abstract excerpt

We conducted a large-scale association study to identify low-penetrance susceptibility alleles for chronic lymphocytic leukemia (CLL), analyzing 992 patients and 2707 healthy controls. To increase the likelihood of identifying disease-causing alleles we genotyped 1467 coding nonsynonymous single nucleotide polymorphisms (nsSNPs) in 865 candidate cancer genes, biasing nsSNP selection toward those predicted to be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia Telangiectasia Mutated Proteins
Share to BRCA2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Cycle

Share to Cell Cycle Proteins

Share to Checkpoint Kinase 2

Share to DNA Damage

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 16574953
DOI: 10.1182/blood-2005-12-5022

Genes

ATM
BRCA2
CHEK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variants in the ATM-BRCA2-CHEK2 axis predispose to chronic lymphocytic leukemia.PMID 16574953Read ↗

Rare Germline ATM Variants Influence the Development of Chronic Lymphocytic Leukemia.Semantic proximity Read ↗

Germline CHEK2 and ATM Variants in Myeloid and Other Hematopoietic Malignancies.Semantic proximity Read ↗

PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.Semantic proximity Read ↗

Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.Semantic proximity Read ↗

Genetic susceptibility variants for chronic lymphocytic leukemia.Semantic proximity Read ↗

A landscape of genetic heterogeneity in germline predisposition to familial chronic lymphocytic leukemiaSemantic proximity Read ↗

Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHVmut and IgHVunmut subgroups.Semantic proximity Read ↗

A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.Semantic proximity Read ↗

Rare germline variants in ATM are associated with chronic lymphocytic leukemia.Semantic proximity Read ↗

ZMYM3 mutations modulate histone acetylation and cooperate with NOTCH1 mutations in chronic lymphocytic leukemiaSemantic proximity Read ↗

Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk.Semantic proximity Read ↗

Molecular genetics of high-risk chronic lymphocytic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.