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Article

Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling.

Gastroenterology - 1 Oct 2012

Anitha Mallappa, Vijay-Kumar Matam, Sitaraman Shanthi V, Gewirtz Andrew T, Srinivasan Shanthi

Abstract excerpt

BACKGROUND & AIMS: Altered gastrointestinal motility is associated with significant morbidity and health care costs. Toll-like receptors (TLR) regulate intestinal homeostasis. We examined the roles of TLR4 signaling in survival of enteric neurons and gastrointestinal motility. METHODS: We assessed changes in intestinal motility by assessing stool frequency, bead expulsion, and isometric muscle recordings of...

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Source

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Identifiers

PMID: 22732731
DOI: 10.1053/j.gastro.2012.06.034
PMCID: PMC3458182

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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