Article

Bowel dysmotility and enteric neuron degeneration in lysosomal storage disease mice is prevented by gene therapy

2023-05-29

Abstract excerpt

<h4>Background and aims</h4> Children with neurodegenerative disease often have debilitating gastrointestinal (GI) symptoms that may be due at least in part to underappreciated involvement of neurons in the enteric nervous system (ENS), the master regulator of bowel function. <h4>Methods</h4> We investigated bowel motility in mouse models of CLN1 and CLN2 disease, neurodegenerative lysosomal storage disorders ca...

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Literature Corpus work: 01b731b1-0446-5c39-a0b3-8fd159d19793
DOI: 10.1101/2023.05.26.542524

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