Article

Segmental regulation of intestinal motility by colitis and the adaptive immune system in the ileum and colon

2024-05-01

Abstract excerpt

Gastrointestinal motility disturbances are common in inflammatory bowel disease (IBD); however, their exact causes remain elusive. This study explores the motility of various intestinal segments in both healthy and IBD states, focusing on the role of the adaptive immune system. Using a dextran sulfate sodium (DSS)-induced colitis model in mice lacking B and T lymphocytes, we evaluated motility in the ileum and col...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 049ea8dc-b95c-5e73-8d48-a2129f2379ee
DOI: 10.1101/2024.04.29.591625

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Segmental regulation of intestinal motility by colitis and the adaptive immune system in the ileum and colonDOI 10.1101/2024.04.29.591625Read

Healthy Intestinal Function Relies on Coordinated Enteric Nervous System, Immune System, and Epithelium ResponsesSemantic proximity Read

Involvement of Enteric Glia in Small Intestine Neuromuscular Dysfunction of Toll-Like Receptor 4-Deficient Mice.Semantic proximity Read

Adventitial macrophage accumulation impairs perivascular nerve function in mesenteric arteries with inflammatory bowel diseaseSemantic proximity Read

The Enteric Nervous System and Its Emerging Role as A Therapeutic TargetSemantic proximity Read

Interaction between the Gut Microbiota and Intestinal MotilitySemantic proximity Read

Interstitial cells of Cajal in health and diseaseSemantic proximity Read

Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling.Semantic proximity Read

Structural and functional gastrointestinal abnormalities in ACTA2 R179H mice modeling multisystemic smooth muscle dysfunction syndrome.Semantic proximity Read

Lack of mucosal cholinergic innervation is associated with increased risk of enterocolitis in Hirschsprung’s diseaseSemantic proximity Read

Impact of disrupting adenosine A₃ receptors (A₃⁻/⁻ AR) on colonic motility or progression of colitis in the mouse.Semantic proximity Read

The role of mast cells in functional GI disorders.Semantic proximity Read

Abnormal enteric nervous system and motor activity in the ganglionic proximal bowel of Hirschsprung’s diseaseSemantic proximity Read