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Article

Polymorphisms in the mitochondrial DNA control region and frailty in older adults.

PloS one - 10 Jun 2010

Moore Ann Z, Biggs Mary L, Matteini Amy, O'Connor Ashley, McGuire Sarah, Beamer Brock A, Fallin M Danielle, Fried Linda P, Walston Jeremy, Chakravarti Aravinda, Arking Dan E

Abstract excerpt

BACKGROUND: Mitochondria contribute to the dynamics of cellular metabolism, the production of reactive oxygen species, and apoptotic pathways. Consequently, mitochondrial function has been hypothesized to influence functional decline and vulnerability to disease in later life. Mitochondrial genet...

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Share to Aged, 80 and over
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Frail Elderly

Share to Frailty in Older Adults

Share to Genetics, Aging, and Longevity in Model Organisms

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Share to Polymorphism, Genetic

Source

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Identifiers

PMID: 20548781
DOI: 10.1371/journal.pone.0011069
PMCID: PMC2883558

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20548781-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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