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Article

Mediator influences telomeric silencing and cellular life span.

Molecular and cellular biology - 1 Jun 2011

Zhu Xuefeng, Liu Beidong, Carlsten Jonas O P, Beve Jenny, Nyström Thomas, Myers Lawrence C, Gustafsson Claes M

Abstract excerpt

The Mediator complex is required for the regulated transcription of nearly all RNA polymerase II-dependent genes. Here we demonstrate a new role for Mediator which appears to be separate from its function as a transcriptional coactivator. Mediator associates directly with heterochromatin at telomeres and influences the exact boundary between active and inactive chromatin. Loss of the Mediator Med5 subunit or...

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Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21482672
DOI: 10.1128/MCB.05242-11
PMCID: PMC3133415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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