Article
A dominant negative mutation of the alpha retinoic acid receptor gene in a retinoic acid-nonresponsive embryonal carcinoma cell.
Molecular and cellular biology - 1 Dec 1990
Pratt M A, Kralova J, McBurney M W
Abstract excerpt
Pluripotential embryonal carcinoma cells such as those of the P19 line differentiate when exposed to retinoic acid (RA). The RAC65 cell line is a mutant clone of P19 cells selected to be RA nonresponsive. RAC65 cells carry a rearrangement affecting one of the genes encoding a nuclear retinoic aci...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Southern
- Carrier Proteins
- Cell Differentiation
- Cell Line
- DNA, Neoplasm
- Drug Resistance
- Gene Library
- Genes
- Genes, Dominant
- Mice
- Molecular Sequence Data
- Mutation
- RNA, Messenger
- Receptors, Retinoic Acid
- Teratoma