Article
Expression of nuclear retinoic acid receptors in wild-type and mutant embryonal carcinoma PCC4.aza1R cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Nov 1990
Nervi C, Vollberg T M, Grippo J F, Lucas D A, George M D, Sherman M I, Shudo K, Jetten A M
Abstract excerpt
Retinoic acid (RA) induces differentiation of murine embryonal carcinoma PCC4.aza1R cells. In this study, the expression of nuclear retinoic acid receptors (RARs) in PCC4.aza1R cells is examined. Analyses of [3H]RA-labeled nuclear extracts prepared from PCC4.aza1R cells by size-exclusion high-performance liquid chromatography demonstrated the presence of a specific RA-binding activity that migrated with a...
Topics
- Animals
- Blotting, Northern
- Carrier Proteins
- Cell Nucleus
- Cycloheximide
- Cytoplasm
- DNA Probes
- Gene Expression
- In Vitro Techniques
- Mice
- Mutation