Alteration of a single amino acid residue in retinoic acid receptor causes dominant-negative phenotype.

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Article

Alteration of a single amino acid residue in retinoic acid receptor causes dominant-negative phenotype.

The Journal of biological chemistry - 22 Jul 1994

Saitou M, Narumiya S, Kakizuka A

Abstract excerpt

Thyroid hormone receptor (TR) and retinoic acid receptor (RAR) are closely related not only in their structures but also in their modes of action. TR and RAR share many amino acids in the functionally important DNA binding domain, ligand binding domain, and heterodimeric interface. To function, b...

Topics

Base Sequence
Carcinoma, Hepatocellular
DNA-Binding Proteins
Genes, Dominant
Humans
In Vitro Techniques
Macromolecular Substances
Molecular Sequence Data
Mutagenesis, Site-Directed
Oligodeoxyribonucleotides
Oncogene Proteins v-erbA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Receptors, Retinoic Acid

Receptors, Thyroid Hormone

Retroviridae Proteins, Oncogenic

Sequence Alignment

Structure-Activity Relationship

Tretinoin

Source

Open in PubMed

Identifiers

PMID: 7913468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7913468-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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