Article
Polymorphisms in the 5-HTR2A gene related to obstructive sleep apnea syndrome.
Brazilian journal of otorhinolaryngology - 1 Jun 2011
Piatto Vânia Belintani, Carvalho Thiago Bittencourt Ottoni de, De Marchi Nely Silva Aragão, Molina Fernando Drimel, Maniglia José Victor
Abstract excerpt
UNLABELLED: Obstructive sleep apnea syndrome (OSAS) is one of the most complex disorders of sleep; it involves several genetic factors that contribute to the phenotype. Serotonin (5-HT) regulates a variety of visceral and physiological functions, including sleep. Gene 5-HTR2A polymorphisms may change the transcription of several receptors in the serotoninergic system, thereby contributing to OSAS. AIM: To...
Topics
- Adolescent
- Adult
- Aged
- Case-Control Studies
- Cross-Sectional Studies
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Receptor, Serotonin, 5-HT2A
- Severity of Illness Index
- Sleep Apnea, Obstructive
- Young Adult