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Telomere DNA Deficiency Is Associated with Development of Human Embryonic Aneuploidy

30 Jun 2011

Abstract excerpt

Aneuploidy represents the most prevalent form of genetic instability found in human embryos and is the leading genetic cause of miscarriage and developmental delay in newborns. Telomere DNA deficiency is associated with genomic instability in somatic cells and may play a role in development of aneuploidy commonly found in female germ cells and human embryos. To test this hypothesis, we developed a method capable...

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PMID: 21738493
DOI: 10.1371/journal.pgen.1002161

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