Article
A 5'-region polymorphism modulates promoter activity of the tumor suppressor gene MFSD2A.
Molecular cancer - 7 Jul 2011
Colombo Francesca, Falvella Felicia S, Galvan Antonella, Frullanti Elisa, Kunitoh Hideo, Ushijima Toshikazu, Dragani Tommaso A
Abstract excerpt
BACKGROUND: The MFSD2A gene maps within a linkage disequilibrium block containing the MYCL1-EcoRI polymorphism associated with prognosis and survival in lung cancer patients. Survival discrepancies between Asians and Caucasians point to ethnic differences in allelic frequencies of the functional genetic variations. RESULTS: Analysis of three single-nucleotide polymorphisms (SNPs) mapping in the MFSD2A...
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