Article
Functional Variant Discovery Identifies a Novel Genetic Link between SPRY2, Wood Smoke, and Asthma.
American journal of respiratory cell and molecular biology - 1 Mar 2026
Gupta Arnav, Dahlin Amber, Macario Alejandra, Gally Fabienne, Weaver Michael R, Guarino Samuel, Kahn Louisa, Sanford Lynn, Gruca Margaret A, Cho Michael H, Dowell Robin D, Weiss Scott T, Sasse Sarah K, Gerber Anthony N
Abstract excerpt
As a consequence of climate change and land-use policies, there has been a historic rise in wildfire smoke across the United States and the world. Although the deleterious effects of wildfire smoke and associated air pollution on asthma outcomes are established epidemiologically, genetic risks and molecular mechanisms of how wildfire smoke affects asthma are unknown. This knowledge gap hinders the identification...
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