Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival.

doi:10.1016/j.lungcan.2006.10.023

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Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival.

Lung cancer (Amsterdam, Netherlands) - 1 Mar 2007

Spinola Monica, Falvella F Stefania, Galvan Antonella, Pignatiello Carmen, Leoni Vera P, Pastorino Ugo, Paroni Rita, Chen Shuqing, Skaug Vidar, Haugen Aage, Dragani Tommaso A

Abstract excerpt

Linkage disequilibrium (LD) analysis to refine a region associated with lung cancer progression on chromosome 1p34 identified a 106 kb LD block that includes MYCL1, TRIT1 (tRNA isopentenyltransferase 1) and MFSD2 (major facilitator superfamily domain-containing 2). Case-only association study on SNPs mapping in TRIT1 and MFSD2 indicated that the rare Leu allele (frequency: 0.04) of the TRIT1 Phe202Leu variation...

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Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival.

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