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Article

Genotyping and molecular dynamic simulations reveal the role of MSH2 DNA repair polymorphisms in lung cancer risk.

Journal of biomolecular structure & dynamics - 1 Jun 2026

Singh Sidhartha, Singh Navneet, Garg Shashank, Chandan Swet, Chaturvedi Mudita, Sharma Siddharth

Abstract excerpt

Lung cancer is the leading cause of cancer-related mortality worldwide and arises from a complex interplay of genetic predispositions and environmental exposures. Epidemiological studies have shown that alterations in key DNA repair genes, such as MSH2, can significantly impact an individual's susceptibility to cancer. In the present study, we focused on MSH2 polymorphisms and their potential role in increasing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41380165
DOI: 10.1080/07391102.2025.2598637

Genes

MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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