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Article

Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Jul 2011

Lazarus Michael, Shen Hai-Ying, Cherasse Yoan, Qu Wei-Min, Huang Zhi-Li, Bass Caroline E, Winsky-Sommerer Raphaelle, Semba Kazue, Fredholm Bertil B, Boison Detlev, Hayaishi Osamu, Urade Yoshihiro, Chen Jiang-Fan

Abstract excerpt

Caffeine, the most widely used psychoactive compound, is an adenosine receptor antagonist. It promotes wakefulness by blocking adenosine A(2A) receptors (A(2A)Rs) in the brain, but the specific neurons on which caffeine acts to produce arousal have not been identified. Using selective gene deletion strategies based on the Cre/loxP technology in mice and focal RNA interference to silence the expression of A(2A)Rs...

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Identifiers

PMID: 21734299
DOI: 10.1523/JNEUROSCI.6730-10.2011
PMCID: PMC3153505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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