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Article

Mice heterozygous for both A1 and A(2A) adenosine receptor genes show similarities to mice given long-term caffeine.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Feb 2009

Yang Jiang-Ning, Björklund Olga, Lindström-Törnqvist Karin, Lindgren Eva, Eriksson Therese M, Kahlström Johan, Chen Jiang-Fan, Schwarzschild Michael A, Tobler Irene, Fredholm Bertil B

Abstract excerpt

Caffeine is believed to exert its stimulant effects by blocking A(2A) and A(1) adenosine receptors (A(2A)R and A(1)R). Although a genetic knockout of A(2A)R eliminates effects of caffeine, the phenotype of the knockout animal does not resemble that of caffeine treatment. In this study we explored the possibility that a mere reduction of the number of A(1)Rs and A(2A)Rs, achieved by deleting one of the two copies...

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Identifiers

PMID: 19036889
DOI: 10.1152/japplphysiol.90971.2008
PMCID: PMC2644247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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