Matrix metalloproteinase-12 (MMP-12) SNP affects MMP activity, lung macrophage infiltration and protects against emphysema in COPD.

doi:10.1136/thx.2011.159087

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Article

Matrix metalloproteinase-12 (MMP-12) SNP affects MMP activity, lung macrophage infiltration and protects against emphysema in COPD.

Thorax - 1 Nov 2011

Haq Imran, Lowrey Gillian E, Kalsheker Noor, Johnson Simon R

Abstract excerpt

BACKGROUND: Recent genetic and animal studies have implicated matrix metalloproteinase-12 (MMP-12) in the pathogenesis of chronic obstructive pulmonary disease (COPD). It has previously been shown that individuals homozygous for the A/A allele of rs652438 in MMP-12 are over-represented among patients with severe COPD (n=1517). A study was undertaken to examine the functional basis of these findings. METHODS:...

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PMID: 21730350
DOI: 10.1136/thx.2011.159087

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