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Article

Airway mucus obstruction triggers macrophage activation and matrix metalloproteinase 12-dependent emphysema.

American journal of respiratory cell and molecular biology - 1 Nov 2014

Trojanek Joanna B, Cobos-Correa Amanda, Diemer Stefanie, Kormann Michael, Schubert Susanne C, Zhou-Suckow Zhe, Agrawal Raman, Duerr Julia, Wagner Claudius J, Schatterny Jolanthe, Hirtz Stephanie, Sommerburg Olaf, Hartl Dominik, Schultz Carsten, Mall Marcus A

Abstract excerpt

Whereas cigarette smoking remains the main risk factor for emphysema, recent studies in β-epithelial Na(+) channel-transgenic (βENaC-Tg) mice demonstrated that airway surface dehydration, a key pathophysiological mechanism in cystic fibrosis (CF), caused emphysema in the absence of cigarette smoke exposure. However, the underlying mechanisms remain unknown. The aim of this study was to elucidate mechanisms of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24828142
DOI: 10.1165/rcmb.2013-0407OC

Genes

MMP12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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