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Article

Airway mucus obstruction triggers macrophage activation and matrix metalloproteinase 12-dependent emphysema.

American journal of respiratory cell and molecular biology - 1 Nov 2014

Trojanek Joanna B, Cobos-Correa Amanda, Diemer Stefanie, Kormann Michael, Schubert Susanne C, Zhou-Suckow Zhe, Agrawal Raman, Duerr Julia, Wagner Claudius J, Schatterny Jolanthe, Hirtz Stephanie, Sommerburg Olaf, Hartl Dominik, Schultz Carsten, Mall Marcus A

Abstract excerpt

Whereas cigarette smoking remains the main risk factor for emphysema, recent studies in β-epithelial Na(+) channel-transgenic (βENaC-Tg) mice demonstrated that airway surface dehydration, a key pathophysiological mechanism in cystic fibrosis (CF), caused emphysema in the absence of cigarette smok...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24828142
DOI: 10.1165/rcmb.2013-0407OC

Genes

MMP12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24828142-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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