Article
New potential eukaryotic substrates of the mycobacterial protein tyrosine phosphatase PtpA: hints of a bacterial modulation of macrophage bioenergetics state.
Scientific reports - 6 Mar 2015
Margenat Mariana, Labandera Anne-Marie, Gil Magdalena, Carrion Federico, Purificação Marcela, Razzera Guilherme, Portela María Magdalena, Obal Gonzalo, Terenzi Hernán, Pritsch Otto, Durán Rosario, Ferreira Ana María, Villarino Andrea
Abstract excerpt
The bacterial protein tyrosine phosphatase PtpA is a key virulence factor released by Mycobacterium tuberculosis in the cytosol of infected macrophages. So far only two unrelated macrophage components (VPS33B, GSK3α) have been identified as PtpA substrates. As tyrosine phosphatases are capable of using multiple substrates, we developed an improved methodology to pull down novel PtpA substrates from an enriched...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.