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Article

The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 2011

Huang Lei, Yan Zheng, Liao Xiaodong, Li Yuan, Yang Jie, Wang Zhu-Gang, Zuo Yong, Kawai Hidehiko, Shadfan Miriam, Ganapathy Suthakar, Yuan Zhi-Min

Abstract excerpt

There are currently two distinct models proposed to explain why both MDM2 and MDMX are required in p53 control, with a key difference centered on whether these two p53 inhibitors work together or independently. To test these two competing models, we generated knockin mice expressing a point mutat...

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Identifiers

PMID: 21730163
DOI: 10.1073/pnas.1102309108
PMCID: PMC3141917

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21730163-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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