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Article

Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry?

Molecular cancer research : MCR - 1 Jan 2009

Wade Mark, Wahl Geoffrey M

Abstract excerpt

Genomic and proteomic profiling of human tumor samples and tumor-derived cell lines are essential for the realization of personalized therapy in oncology. Identification of the changes required for tumor initiation or maintenance will likely provide new targets for small-molecule and biological therapeutics. For example, inactivation of the p53 tumor suppressor pathway occurs in most human cancers. Although this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

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Identifiers

PMID: 19147532
DOI: 10.1158/1541-7786.MCR-08-0423
PMCID: PMC2629357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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