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Gait Abnormalities and Aberrant D2 Receptor Expression and Signaling in a Mouse Model of the Human Pathogenic Mutation DRD2 I212F

2022-06-11

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A dopamine D2 receptor mutation was recently identified in a family with a novel hyperkinetic movement disorder (Mov Disord 36 : 729-739, 2021). That allelic variant D2-I 212 F is a constitutively active and G protein-biased receptor. We now describe mice engineered to carry the D2-I 212 F variant, Drd2 I212F . The mice exhibited gait abnormalities resembling those in other mouse models of chorea and/or dysto...

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Literature Corpus work: 860b36ee-01c3-51b8-8fe2-fbec757e73b4
DOI: 10.1101/2022.06.09.495548

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Gait Abnormalities and Aberrant D2 Receptor Expression and Signaling in a Mouse Model of the Human Pathogenic Mutation <i> DRD2 <sup>I212F</sup> </i>

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