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Article

Abnormal synaptic plasticity in the striatum of mice lacking dopamine D2 receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jun 1997

Calabresi P, Saiardi A, Pisani A, Baik J H, Centonze D, Mercuri N B, Bernardi G, Borrelli E

Abstract excerpt

Dopamine D2 receptors (D2Rs) are of crucial importance in the striatal processing of motor information received from the cortex. Disruption of the D2R gene function in mice results in a severe locomotor impairment. This phenotype has analogies with Parkinson's disease symptoms. D2R-null mice were used to investigate the role of this receptor in the generation of striatal synaptic plasticity. Tetanic stimulation...

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Identifiers

PMID: 9169514
PMCID: PMC6573334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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