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Article

Elevated membrane attack complex in human choroid with high risk complement factor H genotypes.

Experimental eye research - 1 Oct 2011

Mullins Robert F, Dewald Aaron D, Streb Luan M, Wang Kai, Kuehn Markus H, Stone Edwin M

Abstract excerpt

Data from human genetics, histopathology, and animal models reveal a major role for the complement system in the development of age-related macular degeneration (AMD). Genetic variations in the complement factor H (CFH) gene are associated with an elevated risk of AMD. In this study we sought to determine whether eyes from donors with a high-risk genotype (homozygosity for the histidine allele at codon 402)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21729696
DOI: 10.1016/j.exer.2011.06.015
PMCID: PMC3206185

Genes

CFH
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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