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Article

Evaluation of serum and ocular levels of membrane attack complex and C-reactive protein in CFH-genotyped human donors.

Eye (London, England) - 1 Nov 2018

Chirco Kathleen R, Flamme-Wiese Miles J, Wiley Jill S, Potempa Lawrence A, Stone Edwin M, Tucker Budd A, Mullins Robert F

Abstract excerpt

BACKGROUND: There is a considerable body of evidence demonstrating a link between the membrane attack complex (MAC) and age-related macular degeneration (AMD), and between C-reactive protein (CRP) and AMD. Both the MAC and the monomeric form of CRP (mCRP) accumulate within the choriocapillaris in AMD. However, the precise contribution of these species to AMD pathophysiology has not been fully elucidated. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30013157
DOI: 10.1038/s41433-018-0170-8
PMCID: PMC6224589

Genes

CRP
CFH
RPE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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