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Article

CYP2D6 genotyping in natives and immigrants from the Emilia-Romagna Region (Italy).

Genetic testing and molecular biomarkers - 1 Nov 2011

Riccardi Laura N, Lanzellotto Rossana, Luiselli Donata, Ceccardi Stefania, Falconi Mirella, Bini Carla, Pelotti Susi

Abstract excerpt

Pharmacogenetic testing of drug metabolizing enzyme polymorphisms provides an important tool to improve prescribing decisions, avoiding therapeutic failure and adverse drug reactions. Cytochrome P450 2D6 isoform plays an important role in the metabolism of about 20%-25% of widely used clinical drugs. Interethnic differences in allele frequency distribution of the CYP2D6 gene are well established, but interethnic...

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PMID: 21728792
DOI: 10.1089/gtmb.2010.0221

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